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In vitro studies suggest that schisandra has anti-inflammatory (1) (6), anticancer (7) (8), and cardioprotective effects (9). Animal studies also suggest cardio- and liver-protective effects (10) (11) (12). Schisandra appeared to enhance endurance and metabolism (13), improve cognitive functioning (14), and exhibit antimicrobial (15), antioxidant, neuroprotective (16), and anti-hyperglycemic activities (17) (18) (19) in other preclinical models. Active lignans isolated from schisandra, particularly schisandrin A, appeared to reverse P-glycoprotein-mediated multidrug resistance of various cancer cell lines to doxorubicin, vincristine, and paclitaxel (20).

buy schisandra extract

Studies in humans are limited. Some suggest improvements in patients with fatty liver disease or hepatitis C when schisandra is used in combination with other substances (21) (22). In liver transplant patients, schisandra appeared to reduce tacrolimus-associated side-effects of diarrhea and agitation and improve liver function (24). In a small study of renal transplant patients who were CYP3A5 expressers, a schisandra preparation reduced tacrolimus dosing requirements, improved initial dose accuracy, and resulted in fewer dose changes (38). In small studies of women, schisandra did not induce significant changes in obesity-related measures (39), but was helpful for menopausal symptoms (40). A study of a proprietary formulation that included schisandra suggests improved performance of cognitive tasks (23). In older adults doing regular low-intensity exercise, preliminary data suggest supplementation with a schisandra extract may enhance skeletal muscle strength, but it did not affect muscle mass (42).

Lignans in schisandra have been linked to various effects including hepatoprotective (10), antiproliferative, and estrogenic activities (27). In vitro, schisantherins downregulated pro-inflammatory cytokines and mediators by blocking NF-κB and MAPK signaling (1). The anthocyanin Cya-3-O-xylrut has been identified as responsible for its antioxidant activity (18).

In animal toxicity models, pretreatment with schisandra lignans provided liver-protective effects via increased DT-diaphorase activity (10), and improved Phase I drug metabolism (28) (29). Schisandra also increased hepatic glutathione levels and glucose-6-phosphate and glutathione reductase activities (17). It lowered blood glucose levels via inhibition of α-glucosidase activity (19), and improved post-ischemic cardiac function by downregulating inflammatory cytokines, activating the eNOS pathway, inhibiting apoptosis, and enhancing cell proliferation (12). In amyloid-beta-induced memory impairment, schisandra increased superoxide dismutase and glutathione peroxidase activities and glutathione levels in the cerebral cortex and hippocampus of mice while decreasing malondialdehyde and oxidized glutathione (14). It also enhanced endurance and metabolism in rat skeletal muscle by upregulating PGC-1α expression (13).

In human renal cell carcinoma cells, a schisandra polysaccharide identified as SCP induced apoptosis via caspase-3 and -9 activation, increased PARP cleavage, and inactivation of the ERK pathway (8). Another polysaccharide known as SCPP11 exhibited antitumor effects in hepatic cancer models via increased thymus index as well as serum IL-2 and TNF-alpha levels, and enhanced phagocytosis and NO production (26). Pgp-mediated chemotherapy drug-resistance in various cancer cell lines was reversed by schisandrins through the inhibition of Pgp and total protein kinase C function/expression (20).

No serious side effects have been reported, although schisandra is not well studied in humans. A few minor adverse events, such as sleepiness and cold extremities, were observed in both treatment and placebo groups in one small trial (23).

Schisandra is abundant in wellness properties and is regarded for its bounty of antioxidants and for its adaptogenic qualities, along with a lengthy list of other helpful attributes. Schisandra chinensis can be combined into a tea decoction, into herbal brews (soft simmer), or prepared as a liquid extract. This botanical has been revered for its supportive benefits for centuries.

Our schisandra extract is made with organic dried berries in small batches by our expert team for quality and efficacy. This extract is mouthwateringly sour, with some bitterness, and a hint of salt. Schisandra extract goes well with other adaptogenic herbs including ashwagandha extract, rhodiola extract, or reishi extract. Schisandra tincture can be taken with water or juice or added to teas such as easy day tea.

One of the top herbs in the Taoist system, schisandra is known for its ability to harmonise the flow of Qi through the five systems of the human body. It is especially revered for its effects on the Kidney and Liver systems. This nourishing highly adaptive herb helps balance the nervous system, improves brain function, elevates immunity, and through its effects on the overall harmony of the body, assists those who consume it in remaining youthful, both in appearance and physiology.In folk herbalism, it is said that if taken for 100 days consecutively, schisandra purifies the Blood, brings sharpness to the mind, optimises memory, rejuvenates and astringes Kidney Essence (Jing), and supports reproductive function in both men and women. Schisandra also supports the Lung Qi, and may assist in harmonising Lung dysfunction.

Our SuperFeast Schisandra is sourced from China's Changbai Mountains. Many people ask why we chose to source our schisandra from China. Di Dao is the reason!! Di Dao means original source. Schisandra chinensis is a deciduous woody vine in the Magnoliaceae family and is native to Northern China and Eastern Russia. It is now grown in many place in the world including Japan, Korea, and North America. Schisandra is well-researched by Chinese and Russian scientists and is used clinically as well as in their folk medicines.

SuperFeast schisandra berries are harvested at one year old, and must contain a minimum 2% schisandrins (though we don't standardise our herbs and belief that a full-spectrum extract is more useful than one that seeks specific chemical consituents). Schisandra also contains: sesquicarene, phytoestrogens, Ddeoxyschizandrin, schizandrol, stigmasterol and lingans (schisandrin and gomisin A). Fresh berries are a source of vitamins C and E.

Rather like grapes, schisandra berries can be made into juices, wines, teas, desserts, and can be eaten dried or fresh. Sun-dried berries are used in traditional Chinese medicine, and SuperFeast schisandra is harvested by hand and sun-dried to ensure traditional methods of cultivation are upheld. Berries ripen in late summer or early autumn. They are harvested when fully scarlet red - quite the sight to see!

SuperFeast Schisandra is dual-extracted (water and organic rice alcohol) and spray dried to ensure a high-quality herbal extract. We export in a GMP facility in China, where the herbs are tested by fingerprint chromatography to ensure the correct origin, as well as for heavy metals, pesticides, aflatoxins and moulds. This extract is then shipped to our Australian TGA packing facility where it is tested again (to verify it meets TGA standards) and then is packaged for sale. SuperFeast Schisandra meets the stringent TGA standards for herbal quality and is one of the few products in the Australian market to do comply with TGA requirements.

Our SuperFeast Schisandra is sourced from... Schisandra Berry Constituents SuperFeast schisandra berries are harvested at... Schisandra Harvesting and Selection Rather like grapes, schisandra berries can... Schisandra Processing SuperFeast Schisandra is dual-extracted (water and... recipes

The aim of the present study was to investigate the antioxidant and hepatotective effects of Schisandra chinensis pollen extract (SCPE) on CCl4-induced acute liver damage in mice. Total phenolic content, total flavonoid content, individual phenolic compounds and antioxidant activities (1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, chelating activity, and reducing power assay) were determined. In vivo study, SCPE (10, 20 and 40g/kg) administered daily orally for 42days prior to CCl4-intoxicated. Our results showed that SCPE had high total phenolic content (53.741.21mg GAE/g), total flavonoid content (38.290.91mg Rutin/g), quercetin and hesperetin may be the major contributor to strong antioxidant activities. Moreover, SCPE significantly prevented the increase in serum ALT and AST level in acute liver damage induced by CCl4, decreased the extent of malondialdehyde (MDA) formation in liver and elevated the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in liver. The results indicated that SCPE has strong antioxidant activities and significant protective effect against acute hepatotoxicity induced by CCl4, and have been supported by the evaluation of liver histopathology in mice. The hepatoprotective effect may be related to its free radical scavenging effect, increasing antioxidant activity and inhibiting lipid peroxidation.

Recent animal studies have reported beneficial effects of SC extract, for example, its supplementation appears to decrease protein degradation and increase protein synthesis, as well as display antioxidant and anti-inflammatory effects on skeletal muscle fibers [13,14]. Additionally, SC extract was also found to improve mass and strength in skeletal muscle, as well as endurance in mice [13,14,15]. However, in humans, SC extract may not be as effective as in animals. Our first hypothesis is that the supplementation of SC extract in humans can increase muscle strength.

Meanwhile, a recent study by Cao et al. reported that long-term SC supplementation could prevent increased lactate after exercise [15]. However, it is still unclear the effect SC extract has on lactate level at rest and on skeletal muscle strength in humans. Our second hypothesis is that SC extract supplementation in humans reduces lactate at rest. 041b061a72


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